Background: Based on the prodrug principle, aspirin and eugenol, as starting precursors, were esterified to\nsynthesize aspirin eugenol ester (AEE). The aim of the present study was to evaluate the antithrombotic effect of\nAEE in an animal disease model. In order to compare the therapeutic effects of AEE and its precursors, aspirin,\neugenol and a combination of aspirin and eugenol were designed at the same molar quantities as the AEE\nmedium dose in the control group.\nMethods: After oral administration of AEE (dosed at 18, 36 and 72 mg/kg) for seven days, rats were treated with\nk-carrageenan to induce tail thrombosis. Following the same method, aspirin (20 mg/kg), eugenol (18 mg/kg) and\n0.5 % CMC-Na (30 mg/kg) were administered as control drug. Different drug effects on platelet aggregation,\nhemorheology, TXB2/6-keto-PGF1�± ratio and blood biochemistry were studied.\nResults: AEE significantly inhibited ADP and AA-induced platelet aggregation in vivo. AEE also significantly reduced\nblood and plasma viscosity. Moreover, AEE down-regulated TXB2 and up-regulated 6-keto-PGF1�±, normalizing the\nTXB2/6-keto-PGF1�± ratio and blood biochemical profile. In comparison with aspirin and eugenol, AEE produced\nmore positive therapeutic effects than its precursors under the same molar quantity.\nConclusion: It may be concluded that AEE was a good candidate for new antithrombotic and antiplatelet\nmedicine. Additionally, this study may help to understand how AEE works on antithrombosis in different ways.
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